What our users are saying
“Bystro AI lets an investigator use the best available algorithms in the most sophisticated ways with the simplest possible interface by asking the question the same way they would to a colleague.”
David Cutler, PhD
Professor, Emory University
“It's Claude code in the cloud, best bioinformatics vibecoding app out right now. I’m always impressed by the stats chops of the Bystro agent, whereas out-of-the-box LLMs tend to have more limited stats input, unless you really push for more.”
Jacob Boysen, PhD
Researcher
“Bystro is special - For a CEO who needs to get up to speed quickly in detailed areas, Bystro's THiNK has allowed me to get rapid, reliable information and analysis with an impressive amount of error checking. I am a fan.”
David de Graaf, PhD
Co-Founder, CEO & President at Reverb Therapeutics
“To have it actually generate, on the fly, pages of fully valid statistical analysis code, execute that code locally for security, generate volcano plots, and interpret the results was astonishing. This will be transformative for the field.”
Charles DeCarli, MD
Distinguished Professor of Neurology, Victor and Genevieve Orsi Chair in Alzheimer's Research, Co-Director, Alzheimer's Disease Research Center, Chief, Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis
The premise
Genetic analysis used to require technical expertise across multiple fields and six months. We reduced that to a conversation.
From publication-ready cohort analysis to understanding what your own DNA says about drug metabolism with the same grounded agentic AI to power it all.
We don't summarize papers and call it a day. We connect your actual variants with published information, ground every claim in your data, and cite every source. This is more than a chatbot, it's a scientific instrument.
Trusted By
Emory School of Medicine
Department of Neurology
Supported By
See it in action
One answer engine. Limitless discovery.
Bystro brings scientific rigor to every question. Every answer is verified against primary sources. Every analysis is reproducible.
For Everyone
Bystro for Verifying Answers
Ask other AI systems a question. Then ask Bystro if it's right
General-purpose AI hallucinates regularly. Bystro checks any answer against your actual variants, the published literature, and curated databases and shows its work.
- Paste any AI-generated health or genetics answer and stress-test it
- Every disagreement backed by cited literature or database evidence
- Purpose-built on the scientific method, not retrofitted to it
For Individuals
Bystro for Personalized Optimization
Explore personal wellness through genetics
Your genes can affect how your muscles respond to different types of training. Find out what your body is optimized for and train accordingly.
- Muscle fiber type composition analysis
- Recovery and adaptation insights
- Personalized training recommendations
For Researchers
Bystro for Biotech
Clinical Trial Design
Identify genetic subtypes within your cohort and flag individuals unlikely to respond to specific treatments. Design smarter trials by stratifying patients before enrollment.
- Discover genetic subtypes within disease cohorts
- Predict non-responders before treatment begins
- Optimize inclusion criteria for targeted trials
For Clinicians
Bystro for Personalized Health
Investigate Individual Cases
Start with any health question (a symptom, a trait, or just curiosity) and find out if there's a genetic connection. Ask if certain treatments might work differently based on your DNA, all in plain language.
- Find genetic connections to any trait, symptom, or condition
- See how your genetics might affect drug response
- Get references to the research behind each finding
Technology
Built for truth. Not approximations.
The first end-to-end genomic agentic AI designed from the ground up by geneticists where every genetic finding traces directly to your variants grounded by the Bystro Annotator. No black boxes. No guesses. Built for researchers, clinicians, pharmaceutical teams, and motivated individuals who need to be right.
Analysis pipeline
Your Variants
VCF / WGS / SNP array
Bystro Annotator
Peer-reviewed grounding engine
Grounding Agent
Variant-level context injection
Expert Tools
Statistical models + ML pipelines
Evaluation Agent
Verification + citation check
Synthesis Agent
Answer assembly
Verified Answer
Every claim cited and grounded
Analysis pipeline
What makes it different
What makes it different
Your Variants
VCF / WGS / SNP array
A purpose-built verification engine cross-checks every biological claim against your actual variant data. Every reference is validated, not generated.
Bystro Annotator
Peer-reviewed grounding engine
Validated population-genetic models, published effect-size estimators, rigorous association methods. Built by geneticists who publish in the journals you cite, not engineers approximating biology.
Grounding Agent
Variant-level context injection
Proprietary machine learning models developed in collaboration with leading research institutions purpose-built for genomics, not adapted from general-purpose systems. Results currently under peer review.
Expert Tools
Statistical models + ML pipelines
Write Python, build ML pipelines, run custom bioinformatics workflows all inside a secure environment pre-configured around your genomic data. No setup. No duct tape between tools.
Evaluation Agent
Verification + citation check
Already powering research currently under peer review at leading journals. Every analysis is reproducible, exportable, and formatted to the standards reviewers actually expect.
Synthesis Agent
Answer assembly
Algorithms built in active collaboration with leading researchers across academia and industry. When best practices evolve, so does Bystro, because the people setting those standards help build it.
Verified Answer
Every claim cited and grounded
All genetic findings trace back to a specific variant in your data. Researchers and clinicians get the complete audit chain because reproducibility isn't optional.
Platform architecture
The world's deepest genomics annotation engine and the groundbreaking agentic AI that reasons on top of it.
DASH and THiNK are designed to work together, but each is powerful on its own. Understanding which does what is the key to getting the most out of Bystro.
Bystro Classic
DASH
The annotation and dashboard layer. Upload your genetic data and get a comprehensive, structured analysis: ancestry, polygenic risk scores, pharmacogenomics, and variant annotation across 200+ fields. Fast, traceable, reproducible.
gnomAD · dbSNP · CADD+ more databases
What it does
Natural-language variant search
Every one of 200+ annotation fields is OpenSearch-indexed — filter by any arbitrary combination across millions of variants and thousands of samples. No query language, no SQL.
Cross-ancestry polygenic risk scores
Ancestry-corrected scores from any GWAS study with available summary statistics. Bring your own, or use built-in studies for Alzheimer's disease and IBD. No retraining required.
Rich pathogenicity scoring
CADD PHRED scores for SNPs and indels, SpliceAI and Pangolin splice predictions, PolyPhen-2 and SIFT missense impact scores, and PhyloP evolutionary conservation.
Multi-sample cohort support
Single jobs can span thousands of samples. Arrow Feather v2 dosage matrices are ready for downstream ML pipelines and GWAS frameworks the moment annotation completes.
Automatic QC you can trust
Per-sample Ti/Tv ratios, het/hom ratios, missingness rates, Watterson's theta, and silent/replacement ratios generated automatically. Every annotation traceable to a specific database version.
Bystro Agent
THiNK
Not a chatbot. A research collaborator. Ask any question in plain language and THiNK reasons on top of your DASH data, synthesizing the published literature, running custom analyses, and verifying every claim before it answers.
What it does
Runs real analysis, not just reasoning
THiNK executes Python directly in a persistent sandbox: GWAS, PCA, logistic regression, survival analysis, clustering, de novo variant detection, kinship estimation, proteomics integration. Results and publication-quality figures embedded in the conversation, grounded in your DASH data.
Gigabyte-scale uploads
VCFs, FragPipe TMT proteomics data, spreadsheets, PDFs: any file type, any size.
Multi-turn depth
Refine hypotheses, explore alternatives, and run follow-ups all in one continuous thread.
Comprehensive verification
Claims verified against primary sources. Uncertainty flagged. Sources cited.
What it reads
Embedded in DASH annotation
Read directly from your annotated data — no runtime queries
Live internet search
Queried at runtime from primary sources
Literature & Preprints
Pathways, Function & Pharmacogenomics
Raw Data Extraction
DASH produces the grounded data layer: annotated, versioned, and reproducible. THiNK reasons on top of it. When THiNK surfaces a variant or finding worth a closer look, jump to DASH to verify it against the raw annotation and bring that context back into your conversation.
Origin
“After fleeing Chernobyl and losing family members to cancer, I became a geneticist. But the tools to answer important questions were locked behind technical barriers.”
Alex Kotlar — Founder & CEO
So we built the tools ourselves
Your genetic data is arguably the most powerful document in your medical chart. Unlocking it requires programming, statistics, and deep biology.
Those tools didn't exist — so we built them.
Now anyone, from researchers to curious individuals, can ask meaningful questions of their genetic data and get cited, grounded, reproducible answers.
In The News
Media Coverage
Get Started
The genome is complex. Understanding it shouldn't be.
Join researchers and individuals already using Bystro to unlock what their genetics actually say.
Petabyte
Scale data processing
Anywhere
Browser-based, analyze anywhere
Verified
Every claim grounded & cited
Secure
Private servers, on-premises available
Research Use Only — For research, educational, and informational purposes.
Not intended for medical diagnosis, treatment, or clinical use.