Research from the Bystro team

Agentic AI as a Research Partner in Clinical Genomics: Validating Accuracy Against the MSK-IMPACT Benchmark

Martin Zillmann·Bystro White Paper

Generative Principal Component Regression via Variational Inference

Austin Talbot, Corey J. Keller, Cristina Trevino, David E. Carlson, Eric B. Dammer, Erik C. B. Johnson, Thomas S. Wingo, Alex V. Kotlar·IEEE Transactions on Signal Processing

POISE: Spectral Inference of Parent-of-Origin Effects in Unlabeled Genomic Data

Hwang I, Talbot A, Head TS, Trevino CE, Wingo TS, Kotlar AV·bioRxiv

Detecting Batch Heterogeneity via Likelihood Clustering

Talbot A, Ke Y·arXiv

Combining Bayesian and Frequentist Inference for Laboratory-Specific Performance Guarantees in Copy Number Variation Detection

Talbot A, Kotlar AV, Ke Y·arXiv

Beyond Trios: Spectral Inference of Parent-of-Origin Effects in Unlabeled Genomic Data

Cristina Trevino, Ilha Hwang, Austin Talbot, Taylor Head, David Cutler, Michael P. Epstein, Thomas Wingo, Alex Kotlar·ASHG 2025, Boston, MA

Presented by Cristina Trevino

From Gibbs to Genetics: Physics Inspired Estimation and Evaluation of LD Matrices

Austin Talbot, Cristina Trevino, Thomas Wingo, Alex Kotlar·ASHG 2025, Boston, MA

Presented by Austin Talbot

Integrated Fair Machine Learning for Proteomic and Genomic Analysis Workflows

Talbot A, Trevino CE, Seyfried NT, Dammer EB, Johnson ECB, Lah JJ, Wingo AP, Wingo TS, Imam F, Levey AI, Kotlar A·AAIC 2025, Toronto, ON

Presented by Cristina Trevino

PRS without borders: Universal liability-scaled scores for every ancestry

Alex Kotlar, Austin Talbot, Cristina Trevino, Thomas Wingo·ASHG 2025, Boston, MA

Presented by Alex Kotlar

Beyond Bias: Advancing PCA for Genetic Research

Cristina Trevino, Alex Kotlar, Thomas Wingo, Austin Talbot·ASHG 2024, Denver, CO

Presented by Cristina Trevino

Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale

Kotlar AV, Trevino CE, Zwick ME, Cutler DJ, Wingo TS·Genome Biology

In collaboration with Emory University School of Medicine, Atlanta VA Medical Center