Research, insights, and ideas
from the Bystro team.

Deep dives into genomics, the science behind THiNK, and how personalized health is evolving.

Research2026-07-077 min read

Ask Bystro: Can We Catch Critical Typos in Published Manuscripts?

We asked Bystro to audit Ahmad (2022), a statistical paper on high-dimensional covariance proportionality. It found a wrong coefficient in a trace estimator and a missing factor of 2 in the null calibration, then reproduced the failure with spot simulations.

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Ask Bystro: Can We Catch Critical Typos in Published Manuscripts?

Research2026-06-227 min read

Detecting Parent-of-Origin Effects Without Family Data: Introducing POISE

Parent-of-origin effects shape growth, metabolism, and neurodevelopment, but detecting them at scale has required scarce family data. POISE, our new spectral method, recovers these effects from standard GWAS cohorts, outperforms existing tests, and identifies 134 novel loci in the UK Biobank.

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Detecting Parent-of-Origin Effects Without Family Data: Introducing POISE

Research2026-06-117 min read

Discovering Interpretable Omic Networks with gPCR.

Standard SVAES can predict outcome, but not the true network behind it. A new method called gPCR does both, and could transform how scientists design experiments.

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