BYSTRO AIGENETICSGPT

Review Your Search Results

After running any search, Bystro provides a quick summary of your results and tools to help you understand and refine your query. Learn how to interpret result counts, performance metrics, and use the information to improve your analysis.

Search Results Summary

Every search in Bystro displays a simple summary showing exactly what was found and how quickly the search completed.

Search results summary showing variant count, gene count, and timing

The search results summary line provides instant feedback on your query scope and performance

Understanding the Summary

Found 21,353 variants in 18 genes in 0.024s
21,353 variants

Total number of variants matching your search criteria

18 genes

Number of unique genes containing matching variants

0.024s

Query execution time - Bystro's optimized performance

Pagination Information

Below the summary, you'll see pagination details that help you navigate through large result sets efficiently.

Page 1/2,136 (10 results per page)

This shows you're viewing page 1 of 2,136 total pages, with 10 variants displayed per page. You can adjust the results per page or jump to specific pages as needed.

ClinVar Category Breakdown

Bystro automatically categorizes your variants by clinical significance, providing instant insights into the potential impact of your results. Click on any category to filter your results.

ClinVar category breakdown showing pathogenic, benign, protective, and drug response variants

ClinVar category buttons provide quick filtering by clinical significance and risk level

Pathogenic Variants

High/Moderate Risk

Disease-causing variants with established clinical evidence. These require immediate attention in clinical settings.

Benign Variants

Low Risk

Variants with no known clinical significance. Often common population variants.

Protective Variants

Reduces Risk

Variants that may provide protection against certain diseases. Less common but important for research.

Drug Response

Affects Drug Response

Pharmacogenomic variants affecting drug metabolism, efficacy, or adverse reactions.

Other Clinical

Variable Impact

Variants of uncertain significance (VUS) or with conflicting interpretations.

Filters and Aggregation Panel

The Filters and Aggregation panel provides a comprehensive overview of your data by summarizing results across all annotation fields. Click on any field to see value distributions and apply filters.

Filters and Aggregation panel showing expandable field summaries

The Filters and Aggregation panel lets you explore data distributions and apply precise filters

Key Features

  • ✓Expandable summaries for every annotation field
  • ✓Value distributions and frequency counts
  • ✓One-click filtering by clicking values
  • ✓Real-time updates as you refine searches

Useful Field Categories

  • ▶Basic fields: chrom, pos, type, alt
  • ▶Gene info: refSeq.name2, refSeq.siteType
  • ▶Population data: gnomAD frequencies
  • ▶Clinical data: clinvarVcf.CLNSIG

Using the Aggregation Panel Effectively

Start by expanding high-level fields like refSeq.siteTypeor clinvarVcf.CLNSIG to get an overview of your results:

  • • See the distribution of variant types (exonic, intronic, etc.)
  • • Check clinical significance breakdown
  • • Identify most frequent genes or chromosomes
  • • Spot data quality issues or unexpected patterns

Interpreting Your Results

Large Result Sets

  • ⚠10,000+ variants may indicate a broad search
  • ▶Use ClinVar buttons to focus on pathogenic variants
  • ▶Check aggregation panel for dominant categories
  • ▶Filter by exonic variants to focus on coding changes

Small Result Sets

  • ✓Under 1,000 variants is often ideal for analysis
  • ▶Review individual variants in detail
  • ▶Use aggregation panel to understand data composition
  • ▶Ready for export and further analysis

Query Performance

Bystro's optimized indexing typically returns results in under 0.1 seconds, even for complex queries across large datasets. If queries take longer:

  • • Check if you're using very broad search terms
  • • Consider breaking complex queries into smaller parts
  • • Use more specific field searches rather than general text search

Next Steps After Review

Refine Your Search

Too many results? Add filters to narrow down:

  • • Add frequency thresholds
  • • Filter by variant impact
  • • Specify genomic regions

Sort and Prioritize

Organize results by relevance:

  • • Sort by CADD scores
  • • Order by frequency
  • • Group by gene or function

Save Your Results

Preserve your findings:

  • • Save search for later use
  • • Export to analysis tools
  • • Share with collaborators

Pro Tip

The combination of variant count and gene count can tell you a lot about your search scope. Many variants in few genes suggests a focused search, while many variants across many genes indicates a broader exploration that might benefit from additional filtering.